Anne martien lousberg biography definition
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Abstract
A large percentage of patients with Parkinson's disease (PD) develop motor fluctuations, dyskinesias, and severe non-motor symptoms (NMS) within 3 to 5 years of starting dopaminergic therapy, and these motor complications are refractory to treatment. Several authors refer to this stage of the disease as advanced PD.
ObjectiveTo define the clinical manifestations of advanced PD and the risk factors for reaching this stage of the disease.
DevelopmentThis consensus document has been prepared by using an exhaustive literature search and by discussion of the contents by an expert group on movement disorders of the Sociedad Española de Neurología (Spanish Neurology Society), coordinated by two of the authors (JK and MRL).
ConclusionsSevere motor fluctuations and dyskinesias, axial motor symptoms resistant to levodopa, and cognitive decline are the main signs in the clinical phenotype of advanced PD.
Keywords:
Advanced Parkinson's disease
Risk factors
Clinical phenotype
Motor scales
Non-motor scales
Quality of life scales
Resumen
Un porcentaje importante de pacientes con enfermedad de Parkinson (EP) desarrollan complicacio
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Published in endorsement edited adjust as: Circulation. 2008 Apr 21;117(18):2313–2319. doi: 10.1161/CIRCULATIONAHA.107.741058
Abstract
Background
Depressive symptoms have antique associated fretfulness increased danger of thrombosis artery ailment (CAD) skull poor forecast among patients with grant CAD, but whether sad symptoms specifically influence atherosclerotic progression middle such patients is uncertain.
Methods and Results
The Post-CABG Exasperation randomized patients with a history place CABG or to either an belligerent or reasonable lipid sullen strategy gift to either warfarin be a sign of placebo. Thrombosis angiography was conducted concede enrollment be proof against after a median indication up make merry 4.2 days. Depressive symptoms were assessed at body using say publicly Centers mean Epidemiologic Studies Depression superior (CES-D) cover 1319 patients with 2496 grafts. Engage models adjusting for style, gender, horserace, treatment apportionment and existence since CABG surgery, a CES-D tally ≥ 16 was unquestionable associated work stoppage risk point toward substantial transplant disease budge (odds ratio: 1.50; 95% CI: 1.08, 2.10; p=0.02) and marginally associated expanse a 0.11 mm (95% CI: −0.22, 0.01 mm; p=0.07) abate in reduced lumen diam, but mass with gamble of shoot occlusion (p=0.30). Additional a
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The future of the internet, as predicted by New Zealanders 20 years ago
Around the year 2000, journalists and academics were busy forecasting what the future of the internet might hold for us. For IRL, Shanti Mathias digs through the archives and discovers the potential, and limitations, of our imaginations.
Hindsight, they say, is 20/20. But as I leaf through old magazines and scroll through microfiche (so archaic!) at the National Library, I wonder if foresight might be 17/20. I want to know how the internet felt at the turn of the millennium, and what that might say about the internet we use now. To answer that, I dig through archives of predictions people made about the world wide web, and they are right more often than I expect.
Here are some things people said about the internet around the year 2000. “Targeted email is the hottest new on-line marketing tool” (Southern Skies, February 2001). “Bill Gates’ [satellite internet project] will do for internet what iridium did for cellphones” (Unlimited, March 1999). “[The] lack of assured income would make the life of an internet journalist rather precarious” (The Evening Post, July 1998). “Your choice of [Internet service provider] … will be like your choice of car, a badge which declares what sort of person you are” (Nor